CGAS and Parkinson disease: The specific effects of T2DM on neuroinflammation are still unclear, but our study, through the analysis of inflammatory factors, tentatively suggests that T2DM can activate neuroinflammation in microglial cells (Figures 3D–H), leading to the formulation of a mechanistic pathway involving T2DM-mitochondrial damage-cGAS-STING-neuroinflammation-PD.