RELA and hepatocellular carcinoma: Moles et al. (2016) suggest that in p65 T505 mutant mice, sensitivity to liver damage and carbon tetrachloride (CCl4)-induced HCC increases, with significant upregulation of genes associated with proliferation and the cell cycle, as well as significant induction of a gene set related to DNA repair and replication, highlighting the importance of T505 phosphorylation in promoting apoptosis and inhibiting liver cell proliferation.