Knocking out Pin1 was found to significantly inhibit the expression of phosphorylated T254 and S276 in p65, leading to a reduction in NF-κB activity in HepG2 cells, which, in turn, inhibits the progression of hepatocellular carcinoma (HCC) (Shinoda et al., 2015). This evidence concerns the gene RELA and hepatocellular carcinoma.