In animal models of streptozotocin-induced DM, DNA synthesis peaks at day 2 while numerous growth factors, including IGF-1, vascular endothelial growth factor (VEGF), EGF, fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF) have been shown to be upregulated and potentially involved in the early hyperplasia phase [45, 54]. The gene discussed is VEGFA; the disease is diabetes mellitus.