Fascinatingly, an AUC of 0.968 for plasma RHAMM, HA and CD44 signifies even superior diagnostic efficacy for DKD pathogenesis, suggesting that a cell surface triple complex comprising HA, CD44 and RHAMM could potentially serve as a promising targetable biomarker for early intervention in severe renal dysfunctions. The gene discussed is CD44; the disease is diabetic kidney disease.