To further elucidate the location and expression patterns of HA, CD44 and RHAMM in kidney biopsies, the immunohistochemical analysis was performed on a total of 18 renal biopsy specimens obtained from patients with biopsy-proven DN at various stages (stages II, III and IV of Tervaert's renal pathological classification). This evidence concerns the gene CD44 and liver dysplastic nodule.