Also, both genetic and pharmacological inhibition of HDAC3 suppressed extracellular CIRP-induced abnormal activation of RA-FLS in vitro and RGFP966 treatment attenuated arthritis severity of adjuvant arthritis in rats (73), implicating a crucial role of HDAC3 in RA-associated synovial inflammation. This evidence concerns the gene CIRBP and rheumatoid arthritis.