Also, Ergosterol treatment switched macrophage polarization to M2 phenotype with an increase in HDAC3 expression and a reduction in acetyl NF-κB/p65 in COPD models (95), suggesting that ergosterol-mediated protection of COPD is associated with HDAC3-mediated deacetylation. This evidence concerns the gene HDAC3 and chronic obstructive pulmonary disease.