Hyper-glycolytic monocytes of people with obesity showed a normal IL-1ß (Figure 6A), IL-6 (Figure 6B), and TNF response (Figure 6C), whereas the IL-8 secretion in response to LPS was increased compared to monocytes of lean people (Figure 6D). This evidence concerns the gene CXCL8 and obesity due to melanocortin 4 receptor deficiency.