The antigen presentation molecule HLA-DR expressed on myeloid dendritic cells plays a pivotal role in immune response, HLA-DR is a crucial antigen presentation molecule.Myeloid DC expression of HLA-DR DCs enhances their antigen presentation capacity, facilitating the immune system’s response to infections and diseases.In addition,basophil% CD33dim HLA DR - CD66b -CD33 on CD33br HLA DR+ and CD33 on CD33br HLA DR+ are negatively correlated with biliary cancer, while CD80 on myoid DC is positively correlated with biliary cancer. The gene discussed is CD80; the disease is infection.