SYNGAP1-related disorder (SYNGAP1-RD), also known as SYNGAP1 syndrome, is caused by genetic variants in the SYNGAP1 gene and is one of the most prevalent genetic forms of intellectual disability (ID) (Hamdan et al., 2010, 2011; Berryer et al., 2013; Satterstrom et al., 2020; Fu et al., 2022). This evidence concerns the gene SYNGAP1 and intellectual disability, autosomal dominant 5.