While ID and epilepsy are the most penetrant symptoms, some people with SYNGAP1 RD also present with Autism Spectrum Disorder (ASD; ~50%), gastrointestinal distress (~68%), developmental delay, hypersensitivity to sound and light, high pain thresholds (~72%), and challenging behaviors that include increased risk-taking, aggression, and self-injury (~73%) (Pinto et al., 2010; Carvill et al., 2013; Kilinc et al., 2018; Weldon et al., 2018; Jimenez-Gomez et al., 2019; Vlaskamp et al., 2019; Naveed et al., 2023; Thomas et al., 2024). This evidence concerns the gene SYNGAP1 and autism spectrum disorder.