HSP90B2P and amyotrophic lateral sclerosis: In ALS, levels of elements of the HSP system (e.g., HSP70, HSP27 and HSP90) are significantly elevated in SALS patients and HSPs are also significantly elevated in the brains of C9ORF72-ALS/FTD patients (Miyazaki et al., 2016; Mordes et al., 2018).