Han et al. (2022) reported that HIF-1a can induce NID1 expression and activate the PI3K/AKT signaling pathway to promote the metastasis of salivary adenoid cystic carcinoma cells. In addition, Zhang et al. (2018) found that the PI3K/AKT pathway and the expression of VEGF were inhibited after down-regulating HIF-1a, thereby inhibiting the proliferation, migration and invasion of gastric cancer cells. Here, HIF1A is linked to gastric cancer.