EphA2 was first discovered in human cancers more than 30 years ago (Hirai et al., 1987), Subsequently, EphA2 has been studied in various tumors in numerous studies, and more and more evidence suggests that EphA2 is highly expressed in a variety of tumor tissues, including HCC, and is a key regulator of tumorigenesis and progression, which can modulate a variety of malignant biological behaviors of tumor cells through different signaling pathways. The gene discussed is EPHA2; the disease is cancer.