According to our ELISA, RT-qPCR, Western blot, and immunofluorescence results, we found increases in the levels of inflammatory factors (TNF-α, IL-6, IL-1β, and COX2), NF-κB/p-NF-κB ratio, and TLR4 expression and decreases in the expressions of Nrf2 and HO-1 in the in vivo and in vitro VD models. This evidence concerns the gene PTGS2 and sexually transmitted disease.