CGAS and colitis: In a mouse model of colitis-associated colorectal cancer, AOM/DSS, which uses AOM, a carcinogen that induces DNA damage and mutations, along with DSS to establish intestinal inflammation and colonic tumorigenesis, cGAS KO mice were shown to have worsened intestinal inflammation, increased tumorigenesis, and greater dysplasia within tumors (Hu et al., 2021b; Khan et al., 2022).