Focusing specifically on DNA-sensing and nuclease-related genes, a multitude of genes, including RNASEH2A, RNASEH2B, and RNASEH2C, as well as cGAS, STING, TBK1, and IFNB1, were studied in tumor tissue of 53 patients with CRC compared to adjacent normal tissue (Catalano et al., 2020). This evidence concerns the gene CGAS and neoplasm.