VHL and renal cell carcinoma: To unravel the molecular mechanism of how VHL loss stimulates the antitumor immune response, we analyzed a publicly available dataset (accession number: GSE108229) comparing the transcriptional differences between parental 786-O RCC cells that carry a homozygous nonsense mutation in the VHL gene and 786-O cells with ectopic human VHL (hVHL) expression.35