CGAS and neoplasm: Furthermore, the increased intratumoral lymphocyte infiltration observed in Vhl-KO tumors, especially those of CD3+ T, CD8α+ T, and CD8+ GZMB+ T cells, was significantly reduced in Vhl/Sting DKO tumors (Figures S4C–S4H), further supporting the key role of cGAS-STING in Vhl-deficient tumor sensitivity to anti-PD1 blockades.