Although we found no behavioral evidence of age-dependent cognitive decline in the Dp1Tyb strain, we hypothesize that the metabolic products of proteins encoded by key genes on Mmu16, such as App, a gene implicated in the development of Aβ pathology and AD (Cannavo et al., 2020), may promote postsynaptic density loss and neurodegeneration. The gene discussed is APP; the disease is Mental deterioration.