Liu et al. performed MR analyses to test the causal relationship of type 2 diabetes (T2D), fasting glucose, and fasting insulin with two clinical outcomes associated with CSVD (MRI-confirmed lacunar stroke and intracerebral hemorrhage) and three radiological markers of CSVD (WMH, FA and MD) (Liu et al., 2018). The gene discussed is INS; the disease is intracerebral hemorrhage.