TNF and type 2 diabetes mellitus: NET can be appropriately considered as a treatment option because the technique has been shown in a RCT by two of the authors to reduce CRP levels, as well as other inflammatory blood markers associated with stress [such as tumour necrosis factor-α (TNF-α), interleukin-1 (IL-1), and IL-6 (55)], all of which can be predictive of T2D (100).