A randomized controlled trial conducted on 23 male patients aged 15 to 25 years with acne revealed that those who adhered to a low glycemic load (LGL) diet showed significant improvements in acne severity, as well as notable reductions in weight and body mass index (BMI), a significant decrease in the free androgen index, and improved insulin sensitivity at the end of 12 weeks (36). This evidence concerns the gene INS and acne.