BMPR2 and pulmonary arterial hypertension: Soon et al. found that the loss of SOD3 expression in Bmpr2+/− cells was reversed by treating the cells with the histone deacetylase inhibitor trichostatin A. Various microRNAs, histone deacetylases, and abnormal DNA methylation modifications have been linked to PAH, with some specifically implicated in the downregulation of BMPR-II (8, 295, 296).