Decreased expression of ICAM–1: The visualization of the fluorescent micrographs, on the left-hand column, shows a decline of ICAM–1 positive immunoreactive (+IR) nerve fibers after 7 days of cancer cells inoculation, followed by a dramatic decrease to the halfway on day 14, which tries to regenerate on day 21, as compared to sham (Fig. 4 (A–D)). Here, ICAM1 is linked to cancer.