TBC has been linked to mutations in the CYLD gene and is observed in patients with multiple familial trichoepithelioma (MFT) and Brooke-Spiegler syndrome, which is an autosomal dominant disease characterized by the growth of trichoepitheliomas, spiradenomas, cylindromas, or their combination [12]. Here, CYLD is linked to familial multiple trichoepithelioma.