Interferon-alpha-inducible protein 6 (IFI6) is an interferon (IFN)-stimulated protein that is enriched in the inner mitochondrial membrane (Cheriyath et al., 2018); IFI6 is highly expressed in the microvascular endothelial cells (MVECs) of SSc patients with interstitial lung disease (Piera-Velazquez et al., 2021), indicating that IFI6 is involved in the development of SSc vasculopathy. This evidence concerns the gene IFI6 and systemic sclerosis.