IFI6 and inborn error of immunity: Single-gene enrichment analysis showed that IFI6 and FSCN1 were enriched in the intestinal immune network of the immunoglobulin A production pathway in SSc (Figure 8A, B), whereas IFI6 and FSCN1 were enriched in the primary immunodeficiency signaling pathway in patients with AS (Figure 8E, F).