Studies have demonstrated that the transcript (NM_001005273) of CHD3 is more highly expressed in brain tissue, possibly related to the severity of intellectual disability (Mizukami et al., 2021).AII:1 presented with GDD, speech delay, hypotonia, and typical facial features, including forehead bulge and widened eye spacing, complying with the clinical presentation of SNIBCPS (Supplementary Table S2). The gene discussed is CHD3; the disease is Intellectual disability.