Systematic reviews show that despite many potential physical and psychological benefits (i.e., access to risk management to improve personal and familial health, testing-informed targeted treatment approaches), testing positive for BRCA1/2 may also be associated with psychological distress, anxiety, depression, and diminished quality of life (Lombardi et al., 2019; Butler et al., 2021; Isselhard et al., 2023). The gene discussed is BRCA1; the disease is major depressive disorder.