APOE and metabolic syndrome: In this study, four genome-wide significant (association P-value <5 × 10−8) MetS loci in APOA5 (rs651821), CETP (rs56156922), LPL (rs4244457), and APOE (rs429358) also showed strong evidence of an association with lipid traits, implying a genome-wide genetic correlation between MetS and lipid traits (Table 2).