APOE, as a core component of plasma lipoproteins, is involved in their production, conversion, and clearance (Verghese et al., 2013) and is associated with lipoprotein glomerulopathy and hyperlipoproteinemia type III (Evans et al., 2005; Rovin et al., 2007). The gene discussed is APOE; the disease is hyperlipoproteinemia type 3.