Another example is autoantibodies against the neuronal cell adhesion molecule Ig family containing LAMP, OBCAM, and NTM 5 (IgLON5), which causes a subacute encephalopathy with behavioral abnormalities and sleep disorder, but also cognitive impairment in up to 40% of affected patients (8, 9). This evidence concerns the gene IGLON5 and Cognitive impairment.