MC4R and Obesity: Our findings on weight loss using liraglutide and naltrexone-bupropion in patients with MCGO are in line with earlier smaller case series in patients with MC4R deficiency and 16p11.2 deletion syndrome.16, 17, 18 A study in 14 patients with MC4R deficiency treated with liraglutide showed a weight loss comparable to patients with non-genetic forms of obesity.16