For this search, we used broad terms like: “genetic obesity”, “obesity”, “leptin-melanocortin pathway”, “pharmacotherapy”, “glucagon-like peptide-1”, “naltrexone-bupropion”, “naltrexone”, “bupropion”, “anti-obesity agents”, and “anti-obesity medication”. The gene discussed is GCG; the disease is obesity due to melanocortin 4 receptor deficiency.