In one study, the prevalence of enteropathy in seropositive tTG6Abs was 51%,17 but in another study, seropositive anti-tTGIgA patients had no GI symptoms.28 In the present study, among patients with seropositive tTG-2, bloating distention and constipation were the most common GI symptoms, and among patients with seropositive anti-tTG-6 IgA, weakness or fatigue, weight loss, cheilitis, anxiety, depression, arthralgia, and bone pain were the usual extra GI symptoms. The gene discussed is CD79A; the disease is depressive disorder.