UMOD and Bartter syndrome: Mutations in NKCC2 and malfunctions in its regulators are known to cause Bartter syndrome, a salt-depleting hypotensive disorder with reduced levels of UMOD, in addition to a significant reduction in NKCC2 phosphorylation in Umod(-/-) mice, where NKCC2 expression is not as strong as in WT mice, and conversely, mice with overexpressed UMOD exhibit salt-sensitive hypertension (64–66).