TLR4 activation not only promoted the release of proinflammatory mediators (including interleukin-6, interleukin-1, and tumor necrosis factor-α) and facilitated leukocyte migration and infiltration into the renal interstitium [30] but also sustained tubular necrosis and ultimately potentiated renal fibrosis [28]. Here, IL6 is linked to renal fibrosis.