TLR4 activation not only promoted the release of proinflammatory mediators (including interleukin-6, interleukin-1, and tumor necrosis factor-α) and facilitated leukocyte migration and infiltration into the renal interstitium [30] but also sustained tubular necrosis and ultimately potentiated renal fibrosis [28]. This evidence concerns the gene TNF and renal fibrosis.