GSEA showed that the E2F target genes and the MYC target genes were significantly positively enriched (NES = 2.71, p < .001; NES = 2.32, p < .001, respectively) while the p53 pathway genes were significantly negatively enriched (NES = −1.93, p < .001) in tumor organoids compared to normal nasopharyngeal organoids, consistent with their genetic drivers of Cdkn2a deficiency, Myc overexpression and Trp53 loss (Figure S3D, Supporting Information). This evidence concerns the gene CDKN2A and neoplasm.