Then, we introduced NPC‐related genetic alterations into CAG‐Cas9‐EGFP; Trp53‐/‐ nasopharyngeal organoids by mCherry‐linked sgRNA targeting Cdkn2a and overexpressing Myc together with luciferase, which could help to monitor these cells in vivo (Figure S2C and D, Supporting Information). The gene discussed is MYC; the disease is nasopharyngeal carcinoma.