MYC and neoplasm: GSEA showed that the E2F target genes and the MYC target genes were significantly positively enriched (NES = 2.71, p < .001; NES = 2.32, p < .001, respectively) while the p53 pathway genes were significantly negatively enriched (NES = −1.93, p < .001) in tumor organoids compared to normal nasopharyngeal organoids, consistent with their genetic drivers of Cdkn2a deficiency, Myc overexpression and Trp53 loss (Figure S3D, Supporting Information).