EBV infection is strongly associated with NPCs, but EBV is a human‐specific virus and can't infect murine epithelial cells.[32, 33, 34] Given that there is accumulating evidence suggesting that LMP1 would be an important viral oncogene of EBV in NPC and other cancers,[35, 36, 37, 38, 39, 40, 41, 42, 43] we wondered if LMP1 would play significant roles in NPC initiation and progression in our murine models and at least partially mimic the functions of EBV in patients (Figure S5A, Supporting Information). This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.