Our findings are consistent with previous reports on the roles of TGFBR2 in other types of cancers, such as breast cancer,[55] colorectal cancer,[56, 57] and lung cancer.[58] In our mouse OPCM, we show that Tgfbr2 deficiency might promote metastasis through reprogramming the tumor microenvironment, especially increased cancer‐associated fibroblasts. The gene discussed is TGFBR2; the disease is colorectal cancer.