KMT2A and acute myeloid leukemia: The translocation‐induced fusion protein, mixed lineage leukemia (MLL; also known as lysine methyltransferase 2A)‐nuclear receptor‐interacting protein 3 (NRIP3) is responsible for a subset of human AML and is capable of transforming progenitor cells into leukemia stem cells in mice.[14] Murine hematopoietic stem and progenitor cells were transformed into AML cells by MLL‐NRIP3 using a murine stem cell virus (MSCV)‐based method.