In addition to the MLL‐NRIP3‐AML model, 4 °C cold exposure also produced robust anti‐AML and anti‐ALL effects in the MLL‐AF9‐AML and ICN1‐ALL models (Figure S2, Supporting Information), suggesting that cold exposure‐mediated anti‐leukemia effects are likely generalized to other leukemia types. Here, MLLT3 is linked to leukemia.