To investigate the efficacy of PD‐L1‐HGF‐modified exosomes derived from hTERT‐ADSCs (EXO‐PD‐L1‐HGF) in the treatment of ischemic stroke, we used an electroporation system to transduce the PiggyBac (PB)‐CMV‐PD‐L1‐HGF plasmid into hTERT‐ADSCs and isolate EXO‐PD‐L1‐HGF. This evidence concerns the gene HGF and ischemic stroke.