Moreover, immunofluorescence analysis showed that after intravenous injection into C57BL/6 mice at 72 h postischemic stroke, the red fluorescent DiD‐EXO‐PD‐L1‐HGF was co‐localized with glial fibrillary acidic protein (GFAP)‐ or MAP2‐expressing (green fluorescence) cells in the brain with stroke (Figure S10, Supporting Information). The gene discussed is CD274; the disease is Stroke.