NPC1 and Stroke: Moreover, FOXO3 acts as a critical downstream regulator of the phosphoinositide 3‐kinase/AKT pathway and regulates numerous genes involved in various cellular processes such as proliferation, survival, metabolism, differentiation, and the cell cycle.[14] Stroke‐induced NPC cell proliferation, migration, differentiation, and survival are associated with spontaneous functional recovery.[37] However, the role of endogenous NPCs in brain self‐repair and spontaneous functional recovery after a stroke remains unclear.