Intravenous administration of EXO‐PD‐L1‐HGF to the mice with stroke significantly reduced the percentages of CD11c+CD80+ and CD11c+CD86+ (activated dendritic cells), CD3+CD8+IFN‐γ+ (cytotoxic T cells), CD3–NK1.1+ (natural killer cells), and CD11b+CD80+ cells (M1 macrophage cells) (Figure 8b,c), but enhanced the percentages of CD19+IL‐10+ (regulatory B cells), CD8+CD122+IL‐10+ (Treg cells), and CD11b+CD206+F4/80+ cells (M2 macrophage cells) (Figure 8d,e) in the ischemic hemisphere and spleen, as compared with that in the EXO‐treated and control groups. This evidence concerns the gene IL2RB and stroke disorder.