Flavonoids can influence critical cellularprocesses associated with cancer development and progression by modulatingkey molecular targets such as nuclear factor-κB, mitogen-activatedprotein kinases, and phosphoinositide 3-kinase/protein kinase B/mammaliantarget of rapamycin (PI3K/Akt/mTOR).15−20 Likewise, new evidence suggests that flavonoids may have synergisticeffects when taken with traditional chemotherapeutic drugs or radiationtherapy, potentially increasing the efficacy while decreasing sideeffects. This evidence concerns the gene AKT1 and cancer.