Indeed, this disease, partially overlapping with CDD, is a rare and well‐studied neurodevelopmental disorder encompassing the same cardiorespiratory abnormalities (apneas, breathing dysfunction and prolonged QT syndrome; Kaufmann, 2020; Tarquinio et al., 2018; Weese‐Mayer et al., 2006, 2008) recently identified in CDKL5‐KO mice (Fuchs et al., 2018; Gennaccaro et al., 2021; Lo Martire et al., 2017; Loi et al., 2023; Medici et al., 2022). This evidence concerns the gene CDKL5 and craniodiaphyseal dysplasia.