CDKL5 and craniodiaphyseal dysplasia: In contrast, multiple experiments were performed on mice lacking CDKL5 kinase (CDKL5‐knockout [KO]), a widely used animal model that recapitulates the core aspects of human CDD (Amendola et al., 2014), and confirmed the presence of apneas during sleep in both sexes (Fuchs et al., 2018; Gennaccaro et al., 2021; Lo Martire et al., 2017; Medici et al., 2022).