In addition, the neuroanatomical and physiological alterations reported in the present study could be also explained by the direct interaction of the CDKL5 kinase with the methyl‐CpG binding protein 2 (MeCP2; Mari et al., 2005), whose mutation causes the typical form of Rett syndrome (Renieri et al., 2003). Here, MECP2 is linked to atypical Rett syndrome.