However, NfL does not provide topographical information and provides limited information for separating specific disorders of cognitive impairment (e.g., FTD vs AD), prodromal (e.g., CU vs subjective cognitive decline or MCI), or preclinical conditions (e.g., CU Aβ − vs CU Aβ+).47 The gene discussed is NEFL; the disease is Cognitive impairment.