These results show that the Dapa intervention can inhibit the expression of the AT1R-FAK-NOX2 pathway, and the inhibition degree of the AT1R-FAK-NOX2 pathway in the DCM rats with softer myocardial tissues was higher than those of the DCM rats with stiffer myocardial tissues. The gene discussed is AGTR1; the disease is familial dilated cardiomyopathy.