In participants with schizophrenia, orlistat was ineffective to weight or BMI, but the slopes of CHOL (contrast = -0.93, 95% CI: [-1.56, -0.30]) and LDL-CH (contrast = -0.87, 95% CI: [-1.37, -0.36]) were still lower in the orlistat group. This evidence concerns the gene C4B and schizophrenia.