Several studies have revealed associations between serum cholinesterase and acute pancreatitis (Wei et al. 2022), colorectal cancer (Takano et al. 2022), non-small-cell lung cancer (Ran et al. 2022), and Alzheimer’s disease (Shahid Nadeem et al. 2022; Sharma et al. 2020; Sharma 2019). Here, BCHE is linked to early-onset autosomal dominant Alzheimer disease.