Interpretation of HER2 positive results: the score was 0 if positivity was localized to the cell membrane and the membrane was not stained; a score of 1 + indicated that there was weak or faint membrane staining in cancer cells; a score of 2 + denoted that there was weak to moderate staining of the basement membrane, lateral membrane, or intact membrane of tumor cells; and a score of 3 + was given if there was strong staining of the basement membrane, lateral membrane, or intact membrane of the tumor cells. This evidence concerns the gene ERBB2 and cancer.