The top 20 confidence-enriched canonical pathways under the Benjamin-Hochberg test showed in Fig. 3e, and ceramide degradation and biosynthesis, sphingomyelin metabolism, type II diabetes mellitus signaling, triacylglycerol biosynthesis, and endothelin-1 signaling seemed of great importance in the regulation of blood lipids, blood glucose and BP, which are the top three important diagnostic index of MetS. Here, EDN1 is linked to type 2 diabetes mellitus.