EDN1 and metabolic syndrome: The top 20 confidence-enriched canonical pathways under the Benjamin-Hochberg test showed in Fig. 3e, and ceramide degradation and biosynthesis, sphingomyelin metabolism, type II diabetes mellitus signaling, triacylglycerol biosynthesis, and endothelin-1 signaling seemed of great importance in the regulation of blood lipids, blood glucose and BP, which are the top three important diagnostic index of MetS.