In the context of nucleotide-binding oligomerization domain (NOD)-like receptor (NLR), overexpression of TRIM22 reduces the occurrence and development of endometrial cancer, and its inhibition is mediated by the NOD-NF-κB pathway, which may be one of the mechanisms of NLR [149], indicating TRIM22 may emerge as a valuable prognostic indicator in endometrial cancer patients. The gene discussed is TRIM22; the disease is endometrial cancer.