Niederkorn and colleagues suggested that the dysregulation of the TIFAB-USP15 complex, as seen in conditions like del(5q) myelodysplasia or MLL-rearranged leukemia, through the deubiquitination of MDM2 and KEAP1, may lead to a reduction in p53 expression. The gene discussed is KMT2A; the disease is leukemia.