Although the introduction of NSUN2 could well explain the preferential generation of 2Ig B7‐H3 in LN229, U87MG, A172 and U251MG glioma cells, it was still unexplainable that why the wild type U87MG cells had both 4Ig and 2Ig B7‐H3 isomers compared with LN229, even though they both had robust abundance of NSUN2 (Figure 1C). Here, NSUN2 is linked to central nervous system cancer.