The use of urine exosomes as noninvasive biomarkers may have advantages in diagnosing, prognosticating, and monitoring PCa.48 The ExoDx Prostate (IntelliScore) (EPI, Exosome Diagnostics, Waltham, MA, USA) was used to evaluate the exosomal RNA levels of ERG, PCA3, and SAM Pointed Domain ETS Transcription Factor, which are involved in PCa progression. This evidence concerns the gene ERG and posterior cortical atrophy.