Notably, Plxnb2 OE also promoted grafting of syngeneic pancreatic ductal adenocarcinoma (Ptf1a-cre;KrasG12D/+;Trp53flox/+, KPC) and melanoma cells (Tyr-creER;BRafCA;Ptenlox/lox, D4M-3A), suggesting that its seeding-promoting effect also applies to other cancers that frequently metastasize to the liver (Fig. 2c,d). The gene discussed is PLXNB2; the disease is melanoma.