CD4 and neoplasm: We found that vaccination per se resulted in a threefold reduction in the frequencies of CD4+ TILs populating cluster 0 (follicular helper T (TFH) cell cluster (Bcl6+ and Cxcr5+)) and cluster 5 (Treg cell cluster (Foxp3+ and Cd25+)) in tumours from mice receiving either T3-HDVax or T3-LDVax compared with PBS.