Furthermore, mLama4-specific CD8+ TILs from T3-HDVax-treated mice expressed high levels of exhaustion markers (PD1, CD39, TIM3, LAG3 and TOX) and produced low amounts of IFNγ and TNF compared with similar populations from T3-LDVax-treated tumour-bearing mice (Extended Data Fig. 2d–h). This evidence concerns the gene PDCD1 and neoplasm.