RELN and Alzheimer disease: These included co-depletion for entorhinal L5 versus L5-projecting subiculum (Kendall’s τ = 0.37 (AD); −0.1 (non-AD)) or CA1 (τ = 0.42 (AD) and −0.16 (non-AD)); and for CA1 versus L2-lateral EC (LEC, τ = 0.26 (AD) and −0.07 (non-AD)) and L3 RELN+ (τ = 0.24 (AD) and −0.13 (non-AD)) EC neurons, both of which project in part to the CA1 subfield44,45 (Fig. 3b,c and Extended Data Fig. 7g).