GZMB and neoplasm: However, we observed a significant improvement in NK cell function upon silencing circARAP2, manifested by rescued NK92 cell killing of K562 tumor cells (Fig. 3C) and expression of effector molecules such as IFN-γ, Granzyme B, and CD107a in both rsMICA-treated NK92 (Fig. 3D) and human activated NK cells (Fig. S3C).