Similar outcomes were obtained by Mendiola-Precoma et al. [62], who observed that a non-selective adenosine receptor antagonist, theobromine (0.5 and 30 mg/l, po), restored or even increased mRNA levels of Adora1 in a rat brain Alzheimer’s disease model. This evidence concerns the gene ADORA1 and early-onset autosomal dominant Alzheimer disease.