KCNN4 and hepatocellular carcinoma: Intermediate conductance Ca-activated K+ channel-1 (IKCa1) is highly expressed in human hepatocellular carcinoma tissues, and its specific blocker, TRAM-34 (triarylmethane-34), is able to effectively inhibit the proliferation of the human hepatocellular carcinoma cell line HepG2 [50].